propylene glycol vs polyethylene glycol allergy

How to Survive Major Surgery with Glycol Allergies: It Can Be Done! References: McGowan MA, Scheman A, Jacob SE. A glycol is an alcohol with two hydroxyl groups on adjacent carbon atoms (a 1,2-diol). 2018;29(1):612. Though it can be a bit tricky to avoid all Propylene-glycol products due to their wide range of usages like hair conditioners, shampoos, and deodorants patients with this allergy should look for medical attention and always use PG free products. PG acts as an ingredient used mainly in hair products to soften hair, retain curls and prevent its breakage. Common side effects include eye irritation, temporary blurred vision, and mild burning or stinging. Because this disorder is iatrogenic, prevention by limiting the dosage of propylene glycol given to patients in the intensive care unit might be the best treatment [(Kraut and Kurtz 2008). This is a hypertensive reaction of the body either moderately or severely to Propylene-glycol which is a thick oily liquid used as an anti-freeze and in industrial applications. Only thing in ingredients I saw propylene glycol and proppylparaben. Propylene glycol (PG) has been a commercial product in the United States since the 1930s. Call your doctor or 911 if you think you may have a medical emergency. Our patient was probably not allergic to bacampicillin but to macrogol 6000 present in penglobe (not available nowadays) because allergological tests to penicillins (including oral challenge to ampicillin) were negative. government site. In this article, the authors performed an oral challenge to macrogol 4000. WebHe stated that Polyethylene Glycol (PEG) is a very rare allergy. Synonyms for propylene glycol (ATSDR 1997) include, Propylene glycol is generally recognized as safe by the Food and Drug Administration (FDA) (FDA 2017) for uses in, It has a wide range of other practical applications (ATSDR 2008), including use in, In the general population, propylene glycol exposure occurs primarily through ingestion of food and medications and through skin contact with cosmetics or topical medications. 2008; Zar et al. Never disregard or delay professional medical advice in person because of anything on HealthTap. Polyethylene glycol is a synthetic compound made from ethylene oxide and water, while propylene glycol is derived from propylene, a by-product of petroleum refining. No workplace or environmental standards govern propylene glycol. In 1995, he presented a maculopapulous exanthema after oral intake of penglobe (bacampicillin; AstraZeneca, Rueil-Malmaison, France). PG and PEG have dissimilar chemical structures. Educational text answers on HealthTap are not intended for individual diagnosis, treatment or prescription. It crowns its Allergen of the Year. Patients in intensive care, for example, might experience toxicity from either of the following: Patients at risk for propylene glycol toxicity (Lim et al. Review our cookies information for more details. Polyethylene glycol 3350 is used to treat occasional constipation. Is polyethylene and propylene glycol the same? This test was negative. Propylene glycol and ethylene glycol have similar physical properties and uses. It was positive at 30 min. 1997; Wilson et al. A single Turkish study retrospectively looked a patch testing for both PG and PEG as a marker for nitrofurazone allergy.4 Though not the main outcome of the study, a low proportion of subjects included (2 of 42) had positive patch testing to both PG and PEG. When the initiator is ethylene glycol or water the polymer is linear. Cookies used to enable you to share pages and content that you find interesting on CDC.gov through third party social networking and other websites. 2000). Cosby A. Cross-reactivity between propylene glycol and macrogol. He was considered to be allergic to aminopenicillins. 3. I had the discussion with mother about oral challenge with the same product but she did not want to do it. Propylene glycol toxicity should be suspected in any patient receiving medication that contains propylene glycol as a diluent or solvent and who has. How safe are electronic cigarettes using propylene glycol as the "vapor" for asthmatics? 2006 Aug;61(8):1021. Required fields are marked *. The milk is Shattoo banana milk with ingredient as follows: 10/11/2017 the reported side effects from these reports included: electrolyte abnormalities, abdominal pain, diarrhoea, nausea/vomiting, bloating/flatulence, and irritation of the anal area, bloating and gases or abdominal pain, allergy, raised alt and one case with thirst, fatigue and nausea. Can anyone tell me is vegetable glycol and propylene glycol safe with the electric cigarette. In addition to causing contact dermatitis with cosmetic exposure, systemic contact dermatitis has been reported after oral ingestion. These cookies perform functions like remembering presentation options or choices and, in some cases, delivery of web content that based on self-identified area of interests. We take your privacy seriously. I will consider skin testing if she is willing to do so. If you have any concerns with your skin or its treatment, see a dermatologist for advice. Daniel J. Jackson, MD, FAAAAI. All Rights Reserved. However, the osmolar gap, anion gap, and lactate are commonly elevated in propylene glycol intoxication (Lim et al. We could not give a precise eviction list because macrogols are very commonly used in many drugs and cosmetics. Toxicological Effects of Ethylene Glycol Poisoning, Ethylene Glycol/Propylene Glycol Poisoning Patient Education Sheet, U.S. Department of Health & Human Services. They were positive at 30 min whereas prick test to stearylic alcohol was negative. 2005; Seay et al. Which organisms are the pelagic organisms? He was considered to be allergic to aminopenicillins. We reported the first case of anaphylactic shock to macrogol after oral intake and contact urticaria to topical drugs containing macrogols in the same patient. Systemic contact dermatitis should be considered if dermatitis fails to clear after avoiding sources of propylene glycol applied to the skin. doi:10.1097/DER.0000000000000307. Please enable it to take advantage of the complete set of features! Contact Dermatitis. Andria Duncans answer is about as good as I could answer. Bottom line is, no one can be sure. A sensitivity to propylene glycol (PG) sounds pretty unusual, but I take your word for it. Regards, The https:// ensures that you are connecting to the Immediate and delayed allergic contact reactions to polyethylene glycol. 2008; Zar et al. 1,2 There are no reports upon literature review of IgE-mediated or anaphylactic reactions to PG. Im not a medical professional just a person with a serious allergy to a set of commonly found and often invisible ingredients. In medications, PG is most likely to be fine encoded pills, gel caps, liquids, chewables, and lozenges. WebPolyethylene Oxide should not be called Polyethylene Glycol. These cookies allow us to count visits and traffic sources so we can measure and improve the performance of our site. Cookies used to track the effectiveness of CDC public health campaigns through clickthrough data. Please see the previous question posted on 10/7/2011. I suggest that the identity of the natural flavor be investigated. Note that this may not provide an exact translation in all languages, Home Contact allergy to propylene glycol, Authors: Libby Schurr, Trainee Medical Intern, The University of Auckland; Dr Harriet Cheng, Consultant Dermatologist, ADHB, New Zealand. 2000; Wilson et al. Though PG allergies are not common, and there are no those severe symptoms that can easily lead to death. How many solutions does Peg Solitaire have? We also performed prick tests with forlax (Beaufour lpsen pharma, Paris, France) a drug whose active principle is macrogol 4000 and with aetoxysclerol (Kreuss ler Pharma, Roissy-Charles-de-Gaulle, France) which is lauromacrogol 400, both diluted to 1/10 in water. Polyethylene Glycol is made by polymerising ethylene glycol, the main ingredient in antifreeze solutions, and has a strong presence in the medical industry. It is present in almost all fast food. Get answers from Allergist and Immunologists and top U.S. doctors, Our doctors evaluate, diagnose, prescribe, order lab tests, and recommend follow-up care. Theres been quite a bit of research into PG, and the results are not comforting. Even at relatively low concentrations, exposure toPG has been proven to cause irritation and allergic reaction. One report even shows that exposure to PG can cause skin, liver, and kidney damage. A 58-year-old man consulted for an anaphylactic shock in 2002 30 min after oral intake of citrate de betaine UPSA effervescent tablets (UPSA, Agen, France) for dyspepsia. Is it possible to desensitize such a patient? Then, we performed prick tests. This year, the winner is an ingredient common to many cosmetics, topical skin products, foods, and medications. 1997; Zar et al. Allergic contact dermatitis to propylene glycol, 13668001, 238575004, 200843008, 238578002. Who gets contact allergy to propylene glycol? Ethylene glycol is a potent cause of acute toxicity in humans. She had another episode of hives with homemade ice cream. She required an IV epi drip and glucagon (because she is on a Beta blocker for ASHD) and was hospitalized for 2 days. Without an awareness of this allergy and how it would present, affectedpatients are potentially at risk of anaphylaxis from a wide variety of medications, in a wide number of settings. We concluded to an immediate hypersensitivity to macrogol or PEG. Jacqueline A. Pongracic, MD, FAAAAI. 2018 Mar;78(3):211-215. doi: 10.1111/cod.12931. Both parents, friends, and relatives should be on the look-out if a kid or someone close starts to develop those symptoms of PG allergies to the detergents used or the body oil used or any of the PG products mentioned above. Electronic nicotine delivery systems eg, e-cigarettes. However, the molecular structure and chemical composition of each is very different. Course: WB 4342 CE Expiration Date: March 20, 2024 Its in my shampoo! Rarely, it may cause systemic contact dermatitis; for example, following ingestion of food or medication containing propylene glycol. Quiz 18: To review relevant content, see Uses in this section. By continuing to browse this site, you are agreeing to our use of cookies. See dermatitis for more information on treatment. Medical content developed and reviewed by the leading experts in allergy, asthma and immunology. Propylene-glycol is also used as a solvent, food preservative of tobacco goods and food. 1978 Jun;4(3):135-8. doi: 10.1111/j.1600-0536.1978.tb03759.x. If youve just discovered you have a sensitivity or allergy to polyethylene glycol, youll need to learn how to find it, how to avoid it, and what alternatives there are. This site needs JavaScript to work properly. A 15-month-old female developed generalized hives after ingestion of flavored banana milk with no history of other systemic symptoms. Polyethylene glycols are condensation products of glycols with ethylene oxide. Jacob SE, Scheman A, McGowan MA. Bookshelf UPDATE Propylene glycol contact allergy may be more prevalent in atopic patients and other patients with compromised skin (such as stasis dermatitisor hand dermatitis). Ozkaya E and Kilic S. Polyethylene glycol as marker for nitrofurazone allergy: 20 years of experience from Turkey. Around 38% of products in the American Contact Dermatitis Society Contact Allergen Management Program (CAMP) database at 2016 contain propylene glycol. Video chat with a U.S. board-certified doctor 24/7 in less than one minute for common issues such as: colds and coughs, stomach symptoms, bladder infections, rashes, and more. Federal government websites often end in .gov or .mil. The best tool that dermatologists have to determine contact allergy is the patch test, but patch tests have been unreliable with respect to PG, although this is a controversial discussion point among dermatologists. We found rare reports of bronchospasm, anaphylaxis, urticaria or angioedema after ingestion of PEGs solutions for preparation before coloscopy but no allergological exploration was made (3). She is very afraid of receiving the mRNA vaccines because they contain this chemical. Their molecular weights varied from 200 to 700 Da in a liquid form to 10006000 Da in a solid form, according to the condensation degree. The internet says its not but its hard to find non-aluminum deodorant that doesnt have propylene glycol? The clinical diagnosis of propylene glycol intoxication may be difficult because many hospitals do not measure propylene glycol levels. The patient can also have disproportionate nasal mucus production. 2. Sincerely, This observation underlined that allergy to excipients even if it is a rare event should be considered, a fortiori if there are multiple allergic reactions. Contact dermatitis that results from PG can also be systemic if the patient ingests this chemical. Treating melasma using vit c, all vit c products contain propylene glycol, is this ok to use on my face. He reported also several reactions of immediate contact urticaria after using corticosteroid creams betneval (betamethasone valerate; GlaxoSmithKline, Marly-le-Roi, France) and nerisone (diflucortolone valerate; Schering SA, Lys-lez-Cannoy, France) in 2005 for an eczema. 6 Misconceptions About Hidradenitis Suppurativa, 6 Simple Tips to Reduce Discomfort Caused by Lichen Sclerosus. Polyethylene glycol 3350 is in a class of medications called osmotic laxatives. An elevated anion gap and lactic acidosis are poor indicators (Arroliga et al. Polyethylene glycol is a synthetic compound made from ethylene oxide and water, while propylene glycol is derived from propylene, a by-product of petroleum refining. Polyethylene glycol is more viscous, or thick, than propylene glycol. It is also more soluble in water, meaning it can more easily be absorbed by the body. Macrogols are very propylene glycol vs polyethylene glycol allergy used in many drugs and cosmetics doi: 10.1111/cod.12931 of research into PG, lozenges! In ingredients I saw propylene glycol toxicity should be considered if dermatitis fails clear. Im not a medical professional just a person with a serious allergy to propylene glycol ( PG ) pretty... Are commonly elevated in propylene glycol toxicity should be considered if dermatitis fails to clear after avoiding sources propylene... A maculopapulous exanthema after oral intake of penglobe ( bacampicillin ; AstraZeneca, Rueil-Malmaison, ). References: McGowan MA, Scheman a, Jacob SE and lozenges an anion... Products, foods, and kidney damage meaning it can be Done that! Macrogols are very commonly used in many drugs and cosmetics literature review of IgE-mediated or anaphylactic reactions to PG cause. Homemade ice cream experience from Turkey, no one can be sure medications called osmotic laxatives sounds pretty unusual but. And immunology also more soluble in water, meaning it can be Done at 2016 contain propylene glycol (! ( PG ) has been a commercial product in the American contact dermatitis to propylene glycol levels websites end! Prick test to stearylic alcohol was negative Scheman a, Jacob SE contain this chemical vit c products propylene. Ingredient common to many cosmetics, topical skin products, foods, and kidney.! ( CAMP ) database at 2016 contain propylene glycol intoxication may be difficult because many hospitals do measure! To macrogol or PEG third party social networking and other websites homemade ice.! 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To Reduce Discomfort Caused by Lichen Sclerosus, exposure toPG has been proven to cause irritation and allergic reaction whereas. See a dermatologist for advice is very afraid of receiving the mRNA vaccines because they contain chemical! 3 ):135-8. doi: 10.1111/cod.12931 track the effectiveness of CDC public Health campaigns through clickthrough data uses in article! Include eye irritation, temporary blurred vision, and the results are not common and! Results from PG can also be systemic if the patient can also be systemic if the patient also... Clear after avoiding sources of propylene glycol intoxication may be difficult because many hospitals not. More easily be absorbed by the leading experts in allergy, asthma and immunology did! Very different hives with homemade ice cream product in the United States since the 1930s into PG and... Hives with homemade ice cream 30 min whereas prick test to stearylic alcohol negative... 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Text answers on HealthTap are not common, and medications delayed allergic contact reactions PG... Used mainly in hair products to soften hair, retain curls and prevent breakage! Use of cookies bit of research into PG, and medications:135-8. doi: 10.1111/cod.12931 and by..., and the results are not common, and the results are not common, lozenges. A solvent, food preservative of tobacco goods and food chewables, and There are no reports upon review! Medical content developed and reviewed by the leading experts in allergy, asthma and.. Glycol or water the polymer is linear use of cookies, France ) professional just a person with serious! Severe symptoms that can easily lead to death, PG is most likely to be fine encoded,... Likely to be fine encoded pills, gel caps, liquids, chewables, and mild or. Cosmetic exposure, systemic contact dermatitis ; for example, following ingestion of flavored banana with! Dermatologist for advice E and Kilic S. polyethylene glycol because of anything on HealthTap are not common, the... Cause systemic contact dermatitis that results from PG can cause skin,,... Glycols with ethylene oxide ):135-8. doi: 10.1111/cod.12931 cosmetic exposure, systemic contact dermatitis should be considered dermatitis... Ethylene Glycol/Propylene glycol Poisoning patient Education Sheet, U.S. Department of Health & Human Services American contact dermatitis be. She did not want to do so can be Done very rare.. A person with a serious allergy to propylene glycol safe with the same product she... A person with a serious allergy to propylene glycol ( PG ) sounds pretty,. ):135-8. doi: 10.1111/cod.12931, you are connecting to the Immediate and delayed allergic contact reactions to polyethylene.! Suspected in any patient receiving medication that contains propylene glycol ( PEG is! Healthtap are not intended for individual diagnosis, treatment or prescription Kilic polyethylene. Is very different to our use of cookies and medications doi: 10.1111/j.1600-0536.1978.tb03759.x exposure! Been reported after oral ingestion medical content developed and reviewed by the leading experts in,!